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[CAS NO. 1011529-10-4] Azvudine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19314 |
| Brand: | MCE |
| CAS: | 1011529-10-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 286.22 |
| Molecular Formula | C9H11FN6O4 |
| SMILES | O[C@@H]1[C@](CO)(N=[N+]=[N-])O[C@@H](N2C(N=C(N)C=C2)=O)[C@H]1F |
Summary
Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV , HBV and HCV . Azvudine exerts highly potent inhibition on HIV-1 (EC 50 s ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains [1] . Azvudine is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
IC50 & Target
|
HIV-1 0.03-6.92 nM (EC 50 ) |
HIV-2 0.018-0.02 nM (EC 50 ) |
In Vitro
Azvudine (RO-0622) displays strong inhibition on wild-type HIV-1 IIIB and HIV-1 RF with an EC 50 ranging from 30 to 110 pM. The EC 50 values of Azvudine against HIV-1 KM018 , HIV-1 TC-1 and HIV-1 WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-1 74V , PIs-resistant strains HIV-1 L10R/M46I/L63P/V82T/I84V and HIV-1 RF V82F/184V , and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T . The EC 50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively [1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT05633433 | Shanghai Henlius Biotech|Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.|HeNan Sincere Biotech Co., Ltd |
SARS-CoV-2 Infection
|
December 29, 2022 | Phase 2|Phase 3 |
| NCT05642910 | Southeast University, China|Hohhot First Hospital, Hohhot, Inner Mongolia, China |
SARS-CoV-2 Infection
|
October 18, 2022 | Not Applicable |
| NCT05033145 | HRH Pharmaceuticals Limited|GALZU INSTITUTE OF RESEARCH, TEACHING, SCIENCE AND APPLIED TECHNOLOGY, Brazil|Clinical Research Unit + High Complexity Center (CRU+HCC) + Galzu Institute |
COVID-19
|
January 15, 2022 | Phase 3 |
| NCT04668235 | HRH Pharmaceuticals Limited|GALZU INSTITUTE OF RESEARCH, TEACHING, SCIENCE AND APPLIED TECHNOLOGY, Brazil|UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE (UENF), Brazil |
COVID-19
|
April 23, 2021 | Phase 3 |
| NCT05682599 | Shanghai Henlius Biotech|Huashan Hospital|Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.|HeNan Sincere Biotech Co., Ltd |
COVID-19
|
January 6, 2023 | Phase 2 |
| NCT05621993 | Qianfoshan Hospital |
COVID-19 Respiratory Infection
|
November 22, 2022 | |
| NCT05675748 | Shanghai Henlius Biotech|Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.|Huashan Hospital |
COVID-19
|
January 15, 2023 | |
| NCT05697055 | Shandong Provincial Hospital|Central hospital Affiliated to Shandong First Medical University|The Second Affiliated Hospital of Shandong First Medical University|The Affiliated Hospital Of Southwest Medical University|Gansu Provincial Hospital|Rizhao People´s Hospital |
COVID-19
|
January 21, 2023 | Phase 4 |
| NCT05689034 | Peking Union Medical College Hospital |
COVID-19 Respiratory Infection
|
January 20, 2023 | Phase 2|Phase 3 |
| NCT04425772 | HeNan Sincere Biotech Co., Ltd |
COVID-19
|
June 12, 2020 | Not Applicable |
| NCT06006611 | Fifth Affiliated Hospital, Sun Yat-Sen University |
COVID-19
|
August 5, 2023 | |
| NCT04303598 | HeNan Sincere Biotech Co., Ltd |
HIV-infection+Aids
|
April 1, 2020 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 436.73 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4938 mL | 17.4691 mL | 34.9382 mL |
| 5 mM | 0.6988 mL | 3.4938 mL | 6.9876 mL |
| 10 mM | 0.3494 mL | 1.7469 mL | 3.4938 mL |
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