[CAS NO. ] (1S,3R,5R)-PIM447dihydrochloride

Name: (1S,3R,5R)-PIM447dihydrochloride
Brand: Arctom Scientific
SKU: HY-19322C

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PRODUCTS SPECIFICATIONS

Distributor

Catalog

HY-19322C

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	513.38
Molecular Formula	C24H25Cl2F3N4O
SMILES	O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@@H]4C[C@H](N)C[C@H](C)C4)C=CN=C3.Cl.Cl

For research use only. We do not sell to patients.

Summary

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC ₅₀ values of 0.095 μM for Pim1 , 0.522 μM for Pim2 and 0.369 μM for Pim3 .

IC50 & Target

IC50: 0.095 μM (Pim1), 0.52 μM (Pim1), 0.369 μM (Pim1)

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL ( 64.92 mM ; Need ultrasonic)

H ₂ O : 12.5 mg/mL ( 24.35 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9479 mL	9.7394 mL	19.4787 mL
5 mM	0.3896 mL	1.9479 mL	3.8957 mL
10 mM	0.1948 mL	0.9739 mL	1.9479 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.75 mg/mL (5.36 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.75 mg/mL (5.36 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.75 mg/mL (5.36 mM); Clear solution

* All of the co-solvents are available by MCE.