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[CAS NO. ] Potassiumclavulanatecellulose
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19964 |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 238.26 (Potassiumclavulanate) |
| Molecular Formula | C8H9NO5K.(C6H10O5)n |
| SMILES | O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](C)[C@@H](CO)O2)[C@@H](CO)O[C@@H](OC)[C@@H]1O.O=C([C@@H](/C(O[C@]3([H])C4)=C/CO)N3C4=O)O[K].[n] |
2 Publications Citing Use of MCE
Summary
Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Clavulanate potassium is a form of Clavulanic acid. Clavulanate potassium fights bacteria that resistant to penicillins and other antibiotics . Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin [1] [2] .
IC50 & Target
|
β-lactam
|
In Vitro
Clavulanate potassium (2 μg/mL) is susceptive to β-lactamase-positive and β-lactamase-negative
Bacteroides
spp. and
Fusobacterium
spp. with the combination of amoxicillin (4 μg/mL) and ticarcillin (64 μg/mL)
[1]
.
Clavulanate potassium (16 μg/mL) inhibits
B. intermedius
,
B. bivius
,
B. disiens
,
B. oris
,
B. buccae
,
B. buccalis
and
B. loeschei
with MIC
50
values of 8 μg/mL
[1]
.
Clavulanate potassium (16 μg/mL) inhibits
B. melaninogenicus
,
B. oralis
and
F. varium
with MIC
50
values of 16 μg/mL
[1]
.
Clavulanate potassium (2 μg/mL) raises amoxicillin susceptibility rates for β-lactamase-positive
Bacteroides
species and fusobacteria from 41.3 to 90.8% and from 64.2 to 88.7%, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Clavulanate potassium (125 mg; 20 d) protects 75% of mice with experimental pneumonitis compared with no survivors in the control group [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 1 mg/mL (ultrasonic and warming and heat to 80°C)
H 2 O : < 0.1 mg/mL (insoluble)
References
- [1] Appelbaum PC, et al. Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50.
- [2] Beale AS, et al. Comparative activities of amoxycillin, amoxycillin/clavulanic acid and tetracycline against Chlamydia trachomatis in cell culture and in an experimental mouse pneumonitis. J Antimicrob Chemother. 1991 May;27(5):627-38.
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