[CAS NO. ]  Fmoc-Gly-Gly-D-Phe-OtBu

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PRODUCTS SPECIFICATIONS

Store
Catalog
HY-44234A
Brand
MCE
CAS
-

DESCRIPTION

Overview

MDL-
Molecular Weight557.64
Molecular FormulaC32H35N3O6
SMILESO=C([C@H](NC(CNC(CNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O)=O)CC4=CC=CC=C4)OC(C)(C)C

For research use only. We do not sell to patients.

Summary

Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu (HY-44234) [1] .


IC50 & Target

Cleavable


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 179.33 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7933 mL 8.9664 mL 17.9327 mL
5 mM 0.3587 mL 1.7933 mL 3.5865 mL
10 mM 0.1793 mL 0.8966 mL 1.7933 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 5 mg/mL (8.97 mM); Clear solution

* All of the co-solvents are available by MCE.