[CAS NO. 2070009-27-5]  p53andMDM2proteins-interaction-inhibitordihydrochloride

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PRODUCTS SPECIFICATIONS [2070009-27-5]

Catalog
HY-70027A
Brand
MCE
CAS
2070009-27-5

DESCRIPTION [2070009-27-5]

Overview

MDL-
Molecular Weight807.68
Molecular FormulaC40H51Cl4N5O4
SMILESO=C(N1CCN(CC(N2CCOCC2)=O)CC1)N3[C@](C)(C4=CC=C(Cl)C=C4)[C@](C)(C5=CC=C(Cl)C=C5)N=C3C6=CC=C(C(C)(C)C)C=C6OCC.Cl.Cl

For research use only. We do not sell to patients.

Summary

p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 123.81 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2381 mL 6.1906 mL 12.3811 mL
5 mM 0.2476 mL 1.2381 mL 2.4762 mL
10 mM 0.1238 mL 0.6191 mL 1.2381 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.10 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

* All of the co-solvents are available by MCE.