[CAS NO. 2021255-43-4] Ramiprilat-d 5
PRODUCTS SPECIFICATIONS [2021255-43-4]
DESCRIPTION [2021255-43-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 393.49 |
| Molecular Formula | C21H23D5N2O5 |
| SMILES | O=C([C@@H]1C[C@@](CCC2)([H])[C@@]2([H])N1C([C@H](C)N[C@H](C(O)=O)CCC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])=O)O |
Summary
Ramiprilat-d 5 is deuterium labeled Ramiprilat. Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research[1].
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs [1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
- [2] Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research .
