[CAS NO. 1534-35-6] Isolithocholic acid

Name: Isolithocholic acid
Brand: Arctom Scientific
SKU: HY-B0172B

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PRODUCTS SPECIFICATIONS [1534-35-6]

Fulfillment

Catalog

HY-B0172B

Brand

MCE

CAS

1534-35-6

DESCRIPTION [1534-35-6]

Overview

MDL	-
Molecular Weight	376.57
Molecular Formula	C24H40O3
SMILES	C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@H](CC4)O)([H])CC3)C

For research use only. We do not sell to patients.

Summary

Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate ^[1] ^[2] .

IC50 & Target

Microbial Metabolite

In Vitro

Isolithocholic acid at 0.01 % does not inhibit spore germination and outgrowth of CF5 and M120, but it significantly inhibits at the higher concentration (0.1 %). Isolithocholic acid (0.00003 %) prevents growth of CD196, M68, CF5, 630, and BI9 and significant decreases strains CF5, BI9, M120, and 630 in toxin activity. Isolithocholic acid (0.0003 %) makes that all strains displays a significant decrease in toxin activity, except for R20291 and M120 ^[3] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The levels of fecal Isolithocholic acid shows obvious decreases from day 28 onward in the high fat diet (HFD) group compared with rats fed a normal diet ^[4] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 28.57 mg/mL ( 75.87 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6555 mL	13.2777 mL	26.5555 mL
5 mM	0.5311 mL	2.6555 mL	5.3111 mL
10 mM	0.2656 mL	1.3278 mL	2.6555 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% Saline

Solubility: ≥ 2.86 mg/mL (7.59 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.86 mg/mL (7.59 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% Corn Oil

Solubility: ≥ 2.86 mg/mL (7.59 mM); Clear solution

* All of the co-solvents are available by MedChemExpress (MCE).