[CAS NO. 42540-40-9] Cefamandole nafate
PRODUCTS SPECIFICATIONS [42540-40-9]
DESCRIPTION [42540-40-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 512.49 |
| Molecular Formula | C19H17N6NaO6S2 |
| SMILES | O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](OC=O)C4=CC=CC=C4)=O)C1=O)O[Na] |
Summary
Cefamandole nafate (Cefamandole formate sodium) is a second-generation broad-spectrum cephalosporin antibiotic [1] .
IC50 & Target
|
β-lactam |
In Vitro
Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable , allowing delineation of the activity between cefamandole and cefamandole nafate [2] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kgfive days per week for one month
[1]
.
After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights
[1]
.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
References