[CAS NO. 35050-55-6] Tomaymycin

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Catalog:	HY-N10174
Brand:	MCE
CAS:	35050-55-6

Overview

MDL	-
Molecular Weight	304.34
Molecular Formula	C16H20N2O4
SMILES	O=C1N2[C@](C/C(C2)=C\C)([H])[C@H](NC3=CC(O)=C(OC)C=C31)OC

For research use only. We do not sell to patients.

Summary

Tomaymycin is an antitumor antibiotic . Tomaymycin has antimicrobial activity against Grampositive bacteria ^[1] ^[2] .

IC50 & Target

Antibiotic ^[1] ^[2]

In Vivo

Tomaymycin, an antiphage antibiotic is produced by cultivation of Streptomyces achromogenes var. tomaymyceticus in a lactose-bouillon medium enriched with yeast extract and phosphate salts. The antiphage activity is strong against Escherichia coli T1, T3 phages and Bacillus subtilis M-2, SP-10 phages. The LD ₅₀ (i.p.) of tomaymycin for mice is estimated at 3.0 mg/kg.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] F L Boyd, et al. Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry. 1990 Mar 6;29(9):2387-403.
[2] K Arima, et al. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiot (Tokyo). 1972 Aug;25(8):437-44.

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