[CAS NO. 35050-55-6] Tomaymycin
PRODUCTS SPECIFICATIONS [35050-55-6]
DESCRIPTION [35050-55-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 304.34 |
| Molecular Formula | C16H20N2O4 |
| SMILES | O=C1N2[C@](C/C(C2)=C\C)([H])[C@H](NC3=CC(O)=C(OC)C=C31)OC |
Summary
Tomaymycin is an antitumor antibiotic . Tomaymycin has antimicrobial activity against Grampositive bacteria [1] [2] .
In Vivo
Tomaymycin, an antiphage antibiotic is produced by cultivation of Streptomyces achromogenes var. tomaymyceticus in a lactose-bouillon medium enriched with yeast extract and phosphate salts. The antiphage activity is strong against Escherichia coli T1, T3 phages and Bacillus subtilis M-2, SP-10 phages. The LD 50 (i.p.) of tomaymycin for mice is estimated at 3.0 mg/kg.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] F L Boyd, et al. Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry. 1990 Mar 6;29(9):2387-403.
- [2] K Arima, et al. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiot (Tokyo). 1972 Aug;25(8):437-44.