[CAS NO. 269741-97-1]  Avrainvillamide

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PRODUCTS SPECIFICATIONS [269741-97-1]

Catalog
HY-N10264
Brand
MCE
CAS
269741-97-1

DESCRIPTION [269741-97-1]

Overview

MDL-
Molecular Weight445.51
Molecular FormulaC26H27N3O4
SMILESO=C1[C@]23[C@@](C(C)(C4=[N+]([O-])C5=C6C(OC(C)(C=C6)C)=CC=C5C4=C3)C)([H])CC7(C(N2)=O)N1CCC7

For research use only. We do not sell to patients.

Summary

Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic , inhibits growth of multi-agent resistant Staphylococcus aureus , Streptococcus pyogenes , and Enterococcus faecalis , with MICs of 12.5, 12.5 and 25 μg/ml, respectively [1] [2] [3] .


In Vitro

Avrainvillamide ((+)-Avrainvillamide) restores nucleolar localization of certain acute myeloid leukemia (AML)-associated mutant forms of NPM1 and provide evidence that this relocalization is mediated by interactions of Avrainvillamide with mutant NPM1 and exportin-1 (Crm1) [2] .
Avrainvillamide ((+)-Avrainvillamide) shows antiproliferative activities in T-47D (breast cancer) cells and LNCaP (prostate cancer) cells with GI 50 s of 0.33 and 0.42 μM, respectively [2] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.


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Please store the product under the recommended conditions in the Certificate of Analysis.