- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Bioactive Molecules
- Anti-infection
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
- Methylation
- Cytoskeletal Signaling
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. ] Pepstatin Ammonium
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-P0018B |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 702.92 |
| Molecular Formula | C34H66N6O9 |
| SMILES | - |
17 Publications Citing Use of MCE
- [1]Adv Sci (Weinh). 2022 Oct 10;e2203831.
- [2]Sci Adv. 2022 Nov 11;8(45):eabn6579.
- [3]Cell Rep. 2021 Nov 2;37(5):109931.
- [4]Environ Sci Technol. 2017 Dec 5;51(23):13938-13948.
- [5]Cancer Lett. 2022 Mar 9;215629.
- [6]Cell Death Dis. 2022 Dec 16;13(12):1048.
- [7]Pharmacol Res. 2021 Dec 1;175:105985.
- [8]FASEB J. 2022 Jan;36(1):e22121.
- [9]Int J Antimicrob Agents. 2019 Dec;54(6):814-819.
- [10]J Virol. 2021 Sep 22;JVI0153721.
- [11]Int J Oncol. 2019 Jul;55(1):331-339.
- [12]Toxicol Appl Pharmacol. 2018 Oct 1;356:159-171.
- [13]Eur J Pharmacol. 2022 Feb 11;920:174823.
- [14]Biochem Bioph Res Co. 2020 Sep 10;530(1):292-300.
- [15]Mol Med Rep. 2019 Jan;19(1):41-50.
- [16]Biol Pharm Bull. 2022 Feb 3.
- [17]Pharmaceuticals. 2022, 15(12), 1509
Summary
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC 50 s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease [1] [2] .
IC50 & Target
IC50: 4.5 nM (Hemoglobin-pepsin), 6.2 nM (Hemoglobin-proctase), 150 nM (Casein-pepsin), 260 nM (Hemoglobin-acid protease), 290 nM (Casein-proctase), 520 nM (Casein-acid protease) [1]
In Vitro
Pepstatin (Pepstatin A) (7 μM; 48 h) affects the intracellular processing of HIV-specific gag protein [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pepstatin (Pepstatin A) has a very low toxicity, with LD
50
s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route
[1]
.
Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Pylorus ligated male Wistar rats [1] |
| Dosage: | 0.5, 1, 10 and 50 mg/kg |
| Administration: | Oral administration, 15 minutes after pyloric ligation |
| Result: | Effectively prevented stomach ulceration. |
Appearance
Solid
Source
Actinomyces
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 41.67 mg/mL ( 59.28 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.4226 mL | 7.1132 mL | 14.2264 mL |
| 5 mM | 0.2845 mL | 1.4226 mL | 2.8453 mL |
| 10 mM | 0.1423 mL | 0.7113 mL | 1.4226 mL |
References
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.