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[CAS NO. ] L-JNKI-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-P0069A |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 3822.44 |
| Molecular Formula | C164H286N66O40 |
| SMILES | - |
2 Publications Citing Use of MCE
Summary
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK .
IC50 & Target
|
JNK
|
In Vivo
L-JNKI-1 has been shown to effectively inhibit JNK activity in in vivo studies. It is shown that Ang II induces a dose-dependent pressor response, which was significantly attenuated by JNK inhibition [1] . It is also found that 10 μM L-JNKI-1 decreases phosphorylated c-Jun by 98% and phosphorylated Elk-1 by 100%. L-JNKI-1 is able to across the blood-brain barrier and penetrate neurons of adult mice and P5 rats within 1 h after an intraperitoneal injection [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : ≥ 100 mg/mL ( 26.16 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.2616 mL | 1.3081 mL | 2.6161 mL |
| 5 mM | 0.0523 mL | 0.2616 mL | 0.5232 mL |
| 10 mM | 0.0262 mL | 0.1308 mL | 0.2616 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (26.16 mM); Clear solution; Need ultrasonic
References
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