[CAS NO. ] MCH(human, mouse, rat) TFA

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PRODUCTS SPECIFICATIONS

Catalog

HY-P1205A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	2500.86
Molecular Formula	C107H161F3N30O28S4
SMILES	-

For research use only. We do not sell to patients.

Summary

MCH (human, mouse, rat) TFA is a potent peptide agonist of MCH-R and exhibits binding IC ₅₀ values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC ₅₀ values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively ^[1] .

IC50 & Target

Binding IC50: 0.3 nM (MCH1R)
IC50: 1.5 nM (MCH1R) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 39.99 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3999 mL	1.9993 mL	3.9986 mL
5 mM	0.0800 mL	0.3999 mL	0.7997 mL
10 mM	0.0400 mL	0.1999 mL	0.3999 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (1.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (1.00 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (1.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.