[CAS NO. ] CMD178 TFA

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PRODUCTS SPECIFICATIONS

Catelog

HY-P1453A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	964.05
Molecular Formula	C9H8F5KO3Y
SMILES	-

For research use only. We do not sell to patients.

Summary

CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T _reg cell development ^[1] .

In Vitro

CMD178 TFA (100 μM) suppresses IL-2-induced STAT5 phosphorylation and inhibits Foxp3 expression in T cells ^[1] .
CMD178 TFA (100 μM) inhibits the development of T _reg cells induced by IL2/sIL-2Rα signaling ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 2.5 mg/mL ( 2.59 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0373 mL	5.1865 mL	10.3729 mL
5 mM	---	---	---
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Price-Troska T, et, al. Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides. Invest New Drugs. 2019 Feb;37(1):9-16.