[CAS NO. ] Urotensin II, mouse acetate

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PRODUCTS SPECIFICATIONS

Catalog

HY-P1483B

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	1693.91
Molecular Formula	C78H104N18O21S2
SMILES	-

For research use only. We do not sell to patients.

Summary

Urotensin II, mouse acetate is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse acetate is a potent vasoconstrictor. Urotensin II, mouse acetate plays a physiological role in the central nervous system ^[1] .

IC50 & Target

GPR14 ^[1]

In Vivo

Urotensin II is a somatostatin-like cyclic peptide which functions as an arterial vasocontrictor, vasodilator, and bronchoconstriction mediator ^[1] .
Urotensin II (0.1 nmol, 0.3 nmol, and 3 nmol; intracerebroventricular administration) induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6N mice (8 weeks old) ^[1]
Dosage:	0.1 nmol, 0.3 nmol, and 3 nmol
Administration:	Intracerebroventricular (i.c.v.) administration
Result:	Decreased the amount of head dipping without significant alteration of the motor activity.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 59.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.5904 mL	2.9518 mL	5.9035 mL
5 mM	0.1181 mL	0.5904 mL	1.1807 mL
10 mM	0.0590 mL	0.2952 mL	0.5904 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (1.48 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (1.48 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Matsumoto Y, et al. Intracerebroventricular administration of urotensin II promotes anxiogenic-like behaviors in rodents. Neurosci Lett. 2004 Mar 25;358(2):99-102.