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[CAS NO. ] Elabela(19-32) TFA
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-P2106A |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1821.05 |
| Molecular Formula | C77H120F3N25O19S2 |
| SMILES | - |
3 Publications Citing Use of MCE
Summary
Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ) . Elabela(19-32) TFA activates the G αi1 and β-arrestin-2 signaling pathways with EC 50 s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart [1] .
IC50 & Target
IC50: 8.6 nM (G αi1 ) and 166 nM (β-arrestin-2) [1]
In Vitro
Elabela(19-32) TFA (analogue 3) has a K
i
of 0.93 nM for binding of radioligand apelin-13[Glp
65
, Nle
75
, Tyr
77
][
125
I]
[1]
.
Elabela(19-32) TFA has an EC
50
of 36 nM in HEK293 cells transiently expressing the HA-hAPJ receptor. Elabela(19-32) TFA is slightly less potent than apelin-13 and ELA to elicit receptor internalization
[1]
.
Elabela(19-32) TFA (0.001 to 0.3 nM) has an EC
50
of 1.5 pM in inducing changes in left ventricular developed pressure (LVDP) on the Langendorff perfused isolated rat heart
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Elabela(19-32) TFA (analogue 3) is rapidly metabolized in rat plasma (t
1/2
<2 min)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture and light, under nitrogen
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 54.91 mM ; Need ultrasonic)
H 2 O : 33.33 mg/mL ( 18.30 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.5491 mL | 2.7457 mL | 5.4913 mL |
| 5 mM | 0.1098 mL | 0.5491 mL | 1.0983 mL |
| 10 mM | 0.0549 mL | 0.2746 mL | 0.5491 mL |
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