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[CAS NO. ] Cortagine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-P2287 |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 4442.06 |
| Molecular Formula | C192H323N55O63S |
| SMILES | - |
Summary
Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC 50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model [1] .
IC50 & Target
IC50: 2.6 nM (rCRF1) [1]
In Vitro
Cortagine inhibits rCRF1 (EC
50
=0.18 nM) and mCRF
2β
(EC
50
=16 nM) in transfected HEK-293 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL ( 11.26 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.2251 mL | 1.1256 mL | 2.2512 mL |
| 5 mM | 0.0450 mL | 0.2251 mL | 0.4502 mL |
| 10 mM | 0.0225 mL | 0.1126 mL | 0.2251 mL |
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