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[CAS NO. ] Angiopep-2 hydrochloride
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-P2341 |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 2337.93 |
| Molecular Formula | C104H150ClN29O31 |
| SMILES | - |
Summary
In Vitro
Paclitaxel is conjugated to a brain peptide vector, Angiopep-2, to provide a paclitaxel– Angiopep-2 conjugate named ANG1005. ANG1005 enters the brain to a greater extent than paclitaxel and bypasses the P-gp. ANG1005 has an antineoplastic potency similar to that of paclitaxel against human cancer cell lines [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ANG1005 administration leads to a significant increase in the survival of mice with intracerebral implantation of U87 MG glioblastoma cells or NCI-H460 lung carcinoma cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 42.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.4277 mL | 2.1386 mL | 4.2773 mL |
| 5 mM | 0.0855 mL | 0.4277 mL | 0.8555 mL |
| 10 mM | 0.0428 mL | 0.2139 mL | 0.4277 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (42.77 mM); Clear solution; Need ultrasonic
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