[CAS NO. 76600-38-9] Leucinostatin A
PRODUCTS SPECIFICATIONS [76600-38-9]
DESCRIPTION [76600-38-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1218.61 |
| Molecular Formula | C62H111N11O13 |
| SMILES | [P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}] |
Summary
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans . Leucinostatin A is a hydrophobic nonapeptide antibiotic . Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies [1] .
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132.
- [2] Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72.
- [3] Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.