[CAS NO. ]  LEESGGGLVQPGGSMK acetate

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PRODUCTS SPECIFICATIONS

Catalog
HY-P3149B
Brand
MCE
CAS
-

DESCRIPTION

Overview

MDL-
Molecular Weight1605.76
Molecular FormulaC66H112N18O26S
SMILES-

For research use only. We do not sell to patients.

Summary

LEESGGGLVQPGGSMK acetate, a proteolysis peptide, is a component of Infliximab. LEESGGGLVQPGGSMK acetate can be used for quantitative analysis of Infliximab. Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α [1] .


In Vitro

The anti-TNF antibodies blocking the action of TNF alpha revolutionized therapy of TNF-related diseases such as Inflammatory Bowel Disease, lupus, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. By neutralizing TNF activity, anti-TNF antibodies promote mucosal healing and induce long-term remissions in vivo. The main anti-TNF antibodies that are currently authorized encompass Infliximab, Etanercept, Adalimumab, Certolizumab and Golimumab [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

H 2 O : 100 mg/mL ( 62.28 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6228 mL 3.1138 mL 6.2276 mL
5 mM 0.1246 mL 0.6228 mL 1.2455 mL
10 mM 0.0623 mL 0.3114 mL 0.6228 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (62.28 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.