[CAS NO. ] I-309/CCL1 Protein, Human

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PRODUCTS SPECIFICATIONS

Catalog

HY-P70463

Brand

MCE

CAS

DESCRIPTION

Overview

MDL	-
Molecular Weight	Approximately 10.0 kDa
Molecular Formula	-
SMILES	-

For research use only. We do not sell to patients.

Summary

CCL1 Protein, Human is a cytokine that mediates inflammatory immune responses, viral infections, and tumorigenesis by interacting with the CCR8 chemokine receptor on the cell surface and attracting monocytes, natural killer cells, and immature B-cell nuclear dendritic cells. CCL1 Protein, Human is a recombinant human CCL1 (K24-K96) expressed by E. coli ^[1] .

Appearance

Lyophilized powder.

Source

E. coli

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Room temperature in continental US;may vary elsewhere.

References

[1] M D Miller, et al. The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2950-4.
[2] A Zingoni, et al. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol. 1998 Jul 15;161(2):547-51.
[3] Gültekin Tamgüney, et al. Autocrine stimulation of rhadinovirus-transformed T cells by the chemokine CCL1/I-309. Oncogene. 2004 Nov 4;23(52):8475-85.
[4] Nasreen S Haque, et al. Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Blood. 2004 Feb 15;103(4):1296-304.