[CAS NO. ] IL-10R alpha Protein, Human (HEK293, His)

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PRODUCTS SPECIFICATIONS

Catalog

HY-P70692

Brand

MCE

CAS

DESCRIPTION

Overview

MDL	-
Molecular Weight	38-59 kDa
Molecular Formula	-
SMILES	-

For research use only. We do not sell to patients.

Summary

IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a 6*His tag at the C-terminus ^[1] .

Appearance

Lyophilized powder.

Source

HEK293

Shipping

Room temperature in continental US;may vary elsewhere.

References

[1] Dror S Shouval, et al. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014;122:177-210.
[2] J Shi, et al. IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell Death Dis. 2016 Mar 10;7(3):e2133.
[3] L Crepaldi, et al. Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10. J Immunol. 2001 Aug 15;167(4):2312-22.
[4] Nianci Chen, et al. Targeting of IL-10R on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells. Blood Cancer J. 2021 Aug 14;11(8):144.
[5] Douglas J Kominsky, et al. IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol. 2014 Feb 1;192(3):1267-76.