[CAS NO. ] MCP-2/CCL8 Protein, Human

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PRODUCTS SPECIFICATIONS

Catalog

HY-P7238

Brand

MCE

CAS

DESCRIPTION

Overview

MDL	-
Molecular Weight	Approximately 8.9 kDa
Molecular Formula	-
SMILES	-

For research use only. We do not sell to patients.

Summary

MCP-2/CCL8 Protein, Human is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Human is a recombinant human MCP-2/CCL8 (Q24-P99) protein expressed by E. coli ^[1] ^[2] .

Appearance

Lyophilized powder.

Source

E. coli

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Room temperature in continental US; may vary elsewhere.

References

[1] Xiang Zhang, et al. CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling. Lab Invest. 2020 Apr;100(4):619-629.
[2] Jan Korbecki, et al. CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. Int J Mol Sci. 2020 Nov 9;21(21):8412.
[3] Jian Zhou, et al. MCP2 activates NF-κB signaling pathway promoting the migration and invasion of ESCC cells. Cell Biol Int. 2018 Mar;42(3):365-372.