TNF-beta/TNFSF1 Protein, Human
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | Approximately 18.6 kDa |
| Molecular Formula | - |
| SMILES | - |
Summary
TNF-β (tumor necrosis factor β) also called lymphotoxin-α (LT-α), a member of the tumor necrosis factor superfamily, is a cytokine produced by lymphocytes. TNF-β activates the NF-κB signaling pathway, inducing cancer cell proliferation, invasion [1] [2] . TNF-β up-regulates genes connected with metastasis, promotes epithelial-to-mesenchymal-transition, stimulates its own expression [3] . TNF-β mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1 Protein, Human is a recombinant protein consisting of 158 amino acids (L35-L205) and is produced in E. coli .
Appearance
Lyophilized powder.
Source
E. coli
Shipping
Room temperature in continental US; may vary elsewhere.
References
- [1] Buhrmann C, et al. Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes. Arthritis Res Ther. 2013;15(6):R202.
- [2] Buhrmann C, et al. Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it. Exp Biol Med (Maywood). 2019 Jan;244(1):1-12.
- [3] Buhrmann C, et al. Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-B Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-β (Lymphotoxin). Nutrients. 2019 Dec 1;11(12):2904.
- [4] L. Kapas, et al. Tumor necrosis factor-beta induces sleep, fever, and anorexia. Copyright & Permissions. 1992, 703-707.