[CAS NO. ] VEGF-CC Protein, Human (116a.a, HEK293)

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PRODUCTS SPECIFICATIONS

Catalog

HY-P7313

Brand

MCE

CAS

DESCRIPTION

Overview

MDL	-
Molecular Weight	16-19 kDa
Molecular Formula	-
SMILES	-

For research use only. We do not sell to patients.

Summary

VEGF-C Protein, Human (116a.a, HEK293) functions in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration.

Appearance

Lyophilized powder.

Source

HEK293

Shipping

Room temperature in continental US; may vary elsewhere.

References

[1] Joukov V, et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 1996 Jan 15;15(2):290-98.
[2] Tammela T, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation Nature. 2008 Jul 31;454(7204):656-60.
[3] Le Bras B, et al. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci. 2006 Mar;9(3):340-8.
[4] Machnik A, et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med. 2009 May;15(5):545-52.