[CAS NO. ] IL-17A Protein, Mouse (CHO)

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PRODUCTS SPECIFICATIONS

Catalog

HY-P7372

Brand

MCE

CAS

DESCRIPTION

Overview

MDL	-
Molecular Weight	15-22 kDa
Molecular Formula	-
SMILES	-

For research use only. We do not sell to patients.

Summary

IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases ^[1] ^[2] . IL-17A Protein, Mouse (CHO) is a recombinant mouse IL-17A protein and is expressed in CHO cells. It consists of 133 amino acids (A26-A158).

Appearance

Lyophilized powder.

Source

CHO

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Room temperature in continental US; may vary elsewhere.

References

[1] Chen K, et al. Interluekin-17A (IL17A). Gene. 2017 May 30;614:8-14.
[2] Iwakura Y, et al. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev. 2008 Dec;226:57-79.
[3] Cua DJ, et al. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 2010 Jul;10(7):479-89.
[4] Wright JF, et al. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J Immunol. 2008 Aug 15;181(4):2799-805.
[5] Pelidou SH, et al. Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role. Exp Neurol. 2000 May;163(1):165-72.
[6] Liu Y, et al. IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol. 2011 Mar 1;186(5):3197-205.