[CAS NO. ] VEGF121 Protein, Human (120 a.a)

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PRODUCTS SPECIFICATIONS

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HY-P7420

Brand

MCE

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DESCRIPTION

Overview

MDL	-
Molecular Weight	Approximately 28.2 kDa
Molecular Formula	-
SMILES	-

For research use only. We do not sell to patients.

Summary

VEGF121 Protein, Human (205a.a), a VEGF isoform splice variant, cannot bind to heparin. VEGF121 Protein is predictor for survival in activated B-cell-like diffuse large B-cell lymphoma and is related to an immune response gene signature conserved in cancers.

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Lyophilized powder.

Source

E. coli

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Room temperature in continental US; may vary elsewhere.

References

[1] Cohen T, et al. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J Biol Chem. 1995 May 12;270(19):11322-6.
[2] Broséus J, et al. VEGF121, is predictor for survival in activated B-cell-like diffuse large B-cell lymphoma and is related to an immune response gene signature conserved in cancers. Oncotarget. 2017 Jul 19;8(53):90808-90824.
[3] Nakatsu MN, et al. VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model. Lab Invest. 2003 Dec;83(12):1873-85.
[4] Martini M, et al. VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma. BMC Cancer. 2018 May 10;18(1):553.