IP-10/CXCL10 Protein, Rat (P.pastoris, His)
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | Approximately 10 kDa |
| Molecular Formula | - |
| SMILES | - |
Summary
CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. CXCL10 exerts its biological effects by binding to CXCR3. CXCL10 is a pleiotropic molecule capable of exerting potent biological functions, including promoting the chemotactic activity of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation as well as angiogenesis in infectious and inflammatory diseases and cancer [1] . IP-10/CRG-2/CXCL10 Protein, Rat (P.pastoris, His) is produced in P.pastoris with a C-Terminal His-tag. It consists of 77 amino acids (I22-P98).
Appearance
Solution.
Source
P. pastoris
Shipping
Shipping with dry ice.
References
- [1] Liu M, et al. CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev. 2011 Jun;22(3):121-30.
- [2] Huilian Bu, et al. Spinal IFN-γ-induced protein-10 (CXCL10) mediates metastatic breast cancer-induced bone pain by activation of microglia in rat models. Breast Cancer Res Treat. 2014 Jan;143(2):255-63.
- [3] Tim Clarner, et al. CXCL10 triggers early microglial activation in the cuprizone model. J Immunol. 2015 Apr 1;194(7):3400-13.