[CAS NO. ] Carbonic Anhydrase 8 Protein, Human (His)

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PRODUCTS SPECIFICATIONS

Catalog

HY-P7723

Brand

MCE

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DESCRIPTION

Overview

MDL	-
Molecular Weight	Approximately 40.0 kDa
Molecular Formula	-
SMILES	-

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Summary

Carbonic Anhydrase VIII/CA8 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Carbonic anhydrase 8 (CA8), an isozyme of α-carbonic anhydrases (CAs), is an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1), which regulates neuronal intracellular calcium release ^[1] ^[2] .

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Source

E. coli

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References

[1] Gerald Z Zhuang, et al. Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. Gene Ther. 2018 Jul;25(4):297-311.
[2] Min-Syuan Huang, et al. Roles of carbonic anhydrase 8 in neuronal cells and zebrafish. Biochim Biophys Acta. 2014 Sep;1840(9):2829-42.