[CAS NO. 431979-47-4] SJ-172550
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PRODUCTS SPECIFICATIONS [431979-47-4]
Catalog
SLK-E0051
Brand
Selleck
CAS
431979-47-4
DESCRIPTION [431979-47-4]
Overview
| MDL | MFCD03142926 |
|---|---|
| Molecular Weight | 428.87 |
| Molecular Formula | C₂₂H₂₁ClN₂O₅ |
| SMILES | O=C(/C1=C/C2=CC(Cl)=C(OCC(OC)=O)C(OCC)=C2)N(N=C1C)C3=CC=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3317 mL | 11.6585 mL | 23.3171 mL |
| 5 mM | 0.4663 mL | 2.3317 mL | 4.6634 mL |
| 10 mM | 0.2332 mL | 1.1659 mL | 2.3317 mL |
| 50 mM | 0.0466 mL | 0.2332 mL | 0.4663 mL |
Description
SJ 172550 is the first inhibitor that binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
Targets
| MDMX [1] |
In vitro
SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a.
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