[CAS NO. ] BRD0639

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PRODUCTS SPECIFICATIONS

Catalog

SLK-E1007

Brand

Selleck

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	475.948
Molecular Formula	C21H22ClN5O4S
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1011 mL	10.5053 mL	21.0107 mL
5 mM	0.4202 mL	2.1011 mL	4.2021 mL
10 mM	0.2101 mL	1.0505 mL	2.1011 mL
50 mM	0.0420 mL	0.2101 mL	0.4202 mL

Targets

PRMT5-RIOK1 complex ^[1] (in permeabilized cells)	PRMT5-RIOK1 complex ^[1] (in permeabilized cells)
7.5 μM	16 μM

In vitro

BRD0639, which engages the target in Expi293 cells, disrupts PRMT5−RIOK1 complexes, and reduces substrate methylation. BRD0639 also reduces SDMA in the same subset of proteins affected by genetic perturbation of the PBM binding site.

References

[1] David C McKinney, et al. J Med Chem . 2021 Aug 12;64(15):11148-11168.