[CAS NO. 1835283-94-7] Pan-RAS-IN-1
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PRODUCTS SPECIFICATIONS [1835283-94-7]
Catalog
SLK-E1157
Brand
Selleck
CAS
1835283-94-7
DESCRIPTION [1835283-94-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 717.65 |
| Molecular Formula | C36H41Cl2F3N6O2 |
| SMILES | O=C(C1(N)CCNCC1)NCCCN2C=C(C3=CC=C(OC(F)(F)F)C=C3)C4=C2C=CC(CN5CCN(CC6=C(Cl)C=CC=C6Cl)CC5)=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3934 mL | 6.9672 mL | 13.9344 mL |
| 5 mM | 0.2787 mL | 1.3934 mL | 2.7869 mL |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
Pan-RAS-IN-1, a pan-Ras inhibitor, binds to with a Kd less than 20 μM in MST, ITC and NMR assays, also binds to proteins and exhibits lethality in cells partially dependent on expression of Ras proteins.
Targets
| KRasG12D-GppNHp [1] (in ITC and NMR assays) |
| <20 μM(Kd) |
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