[CAS NO. 1451272-71-1] SBI-425

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PRODUCTS SPECIFICATIONS [1451272-71-1]

Catalog

SLK-E1171

Brand

Selleck

CAS

1451272-71-1

DESCRIPTION [1451272-71-1]

Overview

MDL	MFCD31652984
Molecular Weight	341.77
Molecular Formula	C13H12ClN3O4S
SMILES	O=C(C1=CC(NS(=O)(C2=CC(Cl)=CC=C2OC)=O)=CN=C1)N

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

SBI-425, a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase () inhibitor, effectively inhibits in the vasculature, improving cardiovascular parameters and survival.

Targets

tissue-nonspecific alkaline phosphatase, TNAP ^[1] (in the PPi assay)	tissue-nonspecific alkaline phosphatase, TNAP ^[1] (in the whole blood assay)
0.016 μM	0.105 μM

References

[1] Pinkerton AB, et al. Bioorg Med Chem Lett. 2018;28(1):31-34.
[2] Sheen CR, et al. J Bone Miner Res. 2015 May;30(5):824-36.