[CAS NO. 23214-92-8] Doxorubicin

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PRODUCTS SPECIFICATIONS [23214-92-8]

Catalog

SLK-E2516

Brand

Selleck

CAS

23214-92-8

DESCRIPTION [23214-92-8]

Overview

MDL	-
Molecular Weight	543.52
Molecular Formula	C27H29NO11
SMILES	OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8399 mL	9.1993 mL	18.3986 mL
5 mM	0.3680 mL	1.8399 mL	3.6797 mL
10 mM	0.1840 mL	0.9199 mL	1.8399 mL
50 mM	0.0368 mL	0.1840 mL	0.3680 mL

Description

Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits with an IC50 of 2.67 μM, thus stopping DNA replication, and induces , also inhibits human with an IC50 of 0.8 μM.

Targets

topoisomerase I ^[3] (in assay of DNA Topo I activity)	topoisomerase II ^[1] (in decatenation assay for topoisomerase II activity)
0.8 μM	2.67 μM

References

[1] Rhee HK, et al. Bioorg Med Chem. 2007 Feb 15;15(4):1651-8.
[2] Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.
[3] Foglesong PD, et al. Cancer Chemother Pharmacol. 1992;30(2):123-5. doi: 10.1007/BF00686403. PMID: 1318169.

Synonyms

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-

(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

14-Hydroxydaunomycin

Doxorubicin

NSC 123127

Doxil

Caelyx

Evacet

PK 2

Biotransdox

Rubex

Hydroxydaunomycin

Hydroxydaunorubicin

Rubidox

(7S,9S)-7-[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,1 1-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

Liporubicin

Oncodox

Caelix

Livatag

Ameisu