[CAS NO. 878489-28-2] JNJ 303
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PRODUCTS SPECIFICATIONS [878489-28-2]
Catalog
SLK-S0087
Brand
Selleck
CAS
878489-28-2
DESCRIPTION [878489-28-2]
Overview
| MDL | MFCD18086905 |
|---|---|
| Molecular Weight | 440.98 |
| Molecular Formula | C21H29ClN2O4S |
| SMILES | ClC1=CC=C(OC(C)(C)C(N[C@@H]([C@@H](C2)C3)[C@@H]4C[C@H]2C[C@@]3(NS(=O)(C)=O)C4)=O)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2677 mL | 11.3384 mL | 22.6768 mL |
| 5 mM | 0.4535 mL | 2.2677 mL | 4.5354 mL |
| 10 mM | 0.2268 mL | 1.1338 mL | 2.2677 mL |
| 50 mM | 0.0454 mL | 0.2268 mL | 0.4535 mL |
Description
JNJ 303 is a potent blocker of the voltage dependent encoded by with IC50 of 64 nM. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
Targets
| IKs-channel [1] (Cell-free assay) |
| 64 nM |
In vitro
JNJ 303 induces a decrease in I, which is more pronounced in atrial cells compared to ventricular cells.
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