[CAS NO. 942437-37-8] AZD-7325

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PRODUCTS SPECIFICATIONS [942437-37-8]

Catalog

SLK-S0164

Brand

Selleck

CAS

942437-37-8

DESCRIPTION [942437-37-8]

Overview

MDL	MFCD21337369
Molecular Weight	354.38
Molecular Formula	C19H19FN4O2
SMILES	O=C(C1=NN=C2C(C3=C(OC)C=CC=C3F)=CC=CC2=C1N)NCCC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8218 mL	14.1091 mL	28.2183 mL
5 mM	0.5644 mL	2.8218 mL	5.6437 mL
10 mM	0.2822 mL	1.4109 mL	2.8218 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL

Description

AZD7325 is a potent and orally active partial selective Positive allosteric modulator (PAM) of with Ki=0.3 and 1.3 nM, respectively, and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes.

Targets

Aα1 ^[2]	Aα5 receptor ^[2]	GABAAα2 ^[2]	Aα3 ^[2]
		0.3 nM(Ki)	1.3 nM(Ki)

References

[1] Chen X, et al.Br J Clin Pharmacol. 2014 Dec;78(6):1298-314.
[2]Artelsmair M, et al. J Labelled Comp Radiopharm. 2018 May 15;61(5):415-426.