[CAS NO. 189349-50-6] L-765314

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PRODUCTS SPECIFICATIONS [189349-50-6]

Catalog

SLK-S0862

Brand

Selleck

CAS

189349-50-6

DESCRIPTION [189349-50-6]

Overview

MDL	MFCD05664727
Molecular Weight	522.60
Molecular Formula	C27H34N6O5
SMILES	O=C(N1[C@H](C(NC(C)(C)C)=O)CN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)OCC4=CC=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9135 mL	9.5675 mL	19.1351 mL
5 mM	0.3827 mL	1.9135 mL	3.8270 mL
10 mM	0.1914 mL	0.9568 mL	1.9135 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL

Description

L-765314 is a selective and potent antagonist with an IC50 of 1.90 nM and Kis of 5.4 and 2.0 for rat and human α1b adrenergic receptor, respectively.

Targets

α1b-adrenoceptor ^[1]	α1b-adrenoceptor ^[1] (in receptor binding affinity to human experiment)	α1b-adrenoceptor ^[1] (in receptor binding affinity to rat experiment)
1.9 nM	2 μM(Ki)	5.4 μM(Ki)

In vitro

L-765,314 is a potent and selective α1b adrenergic receptor antagonist, which also reduces melanin production by targeting the protein kinase C (PKC)-dependent regulation of tyrosinase activity and raises the intracellular level of melanin precursors.

References

[1] Patane MA, et al. Journal of Medicinal Chemistry, 41(8), 1205–1208.
[2] Kim J, et al. Molecules. 2019 Feb 21;24(4):773.