[CAS NO. 305350-87-2] SL-327
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PRODUCTS SPECIFICATIONS [305350-87-2]
Distributor
Catalog
SLK-S1066
Brand
Selleck
CAS
305350-87-2
DESCRIPTION [305350-87-2]
Overview
| MDL | MFCD06411432 |
|---|---|
| Molecular Weight | 335.35 |
| Molecular Formula | C16H12F3N3S |
| SMILES | C(=C(SC1=CC=C(N)C=C1)N)(C#N)C2=C(C(F)(F)F)C=CC=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9820 mL | 14.9098 mL | 29.8196 mL |
| 5 mM | 0.5964 mL | 2.9820 mL | 5.9639 mL |
| 10 mM | 0.2982 mL | 1.4910 mL | 2.9820 mL |
| 50 mM | 0.0596 mL | 0.2982 mL | 0.5964 mL |
Description
SL327 is a selective inhibitor for with of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.
In vitro
SL327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII.
In vivo
SL327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation. SL327 (30 mg/kg) significantly impairs spatial learning in mice. SL327 (50 mg/kg) blocks cocaine-induced properties.
References
Synonyms
Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
SL 327
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