[CAS NO. 553-21-9] Costunolide

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PRODUCTS SPECIFICATIONS [553-21-9]

Catalog

SLK-S1319

Brand

Selleck

CAS

553-21-9

DESCRIPTION [553-21-9]

Overview

MDL	MFCD00210262
Molecular Weight	232.32
Molecular Formula	C15H20O2
SMILES	C=C1[C@]2([C@](OC1=O)(/C=C(\C)/CC/C=C(\C)/CC2)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.3044 mL	21.5220 mL	43.0441 mL
5 mM	0.8609 mL	4.3044 mL	8.6088 mL
10 mM	0.4304 mL	2.1522 mL	4.3044 mL
50 mM	0.0861 mL	0.4304 mL	0.8609 mL

Description

Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits with of 20 μM, also inhibits with of 65-90 μM.

Targets

FPTase ^[2]	Telomerase (MDA-MB-231) ^[1]	Telomerase (MCF-7) ^[1]
20 μM	65 μM	90 μM

In vitro

Costunolide inhibits the growth and telomerase activity of MCF-7 and MDA-MB-231 cells in a concentration- and time-dependent manner. Costunolide also inhibits the farnesylation process of human lamin-B by farnesyl–proteinttransferase (FPTase), in a dose dependent manner. Continuously treatment of Costunolide for 48 hours will significantly decrease proliferation of human tumor cells (A549, SK-OV-3, SK-MEL-2, XF498 and HCT-1) in a dose-dependent manner. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release to the cytosol in HL-60 human leukemia cells. A recent study indicates that Costunolide shows significant antifungal activity, including , , , and so on.

In vivo

Costunolide inhibits angiogenic response by blocking the angiogenic factor signaling pathway. In a mouse corneal micropocket assay, Costunolide reduces VEGF-stimulated neovascularization in mice.

References

[1] Choi SH, et al, Cancer Lett, 2005, 227(2), 153-162.
[2] Park SH, et al, Planta Med, 2001, 67(4), 358-359.
[3] Lee MG, et al, Biol Pharm Bull, 2001, 24(3), 303-306.
[4] Duripandiyan V, et al, BMC Complement Altern Med, 2012, 12, 13.
[5] Jeong SJ, et al, Cancer Lett, 2002, 187(1-2), 129-133.

Synonyms

Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-

Germacra-1(10),4,11(13)-trien-12-oic acid, 6α-hydroxy-, γ-lactone, (E,E)-

Costunolide

Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, [3aS-(3aR*,6E,10E,11aS*)]-

(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one

Costus lactone

Costunolid

(+)-Costunolide

NSC 106404