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[CAS NO. 147127-20-6] Tenofovir
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | SLK-S1401 |
| Brand: | Selleck |
| CAS: | 147127-20-6 |
Overview
| MDL | MFCD00943794 |
|---|---|
| Molecular Weight | 287.21 |
| Molecular Formula | C9H14N5O4P |
| SMILES | C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4818 mL | 17.4089 mL | 34.8177 mL |
| 5 mM | 0.6964 mL | 3.4818 mL | 6.9635 mL |
| 10 mM | 0.3482 mL | 1.7409 mL | 3.4818 mL |
| 50 mM | - | - | - |
Description
Tenofovir (GS-1278) blocks and hepatitis B virus infections.
Features
Tenofovir disoproxil fumarate is the prodrug form of tenofovir.
Targets
| Reverse transcriptase [1] |
In vitro
Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT.
In vivo
Tenofovir (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques.
References
[1] Witvrouw M, et al. Antivir Ther, 2004, 9(1), 57-65.
[2] Miller MD, et al. Nucleosides Nucleotides Nucleic Acids, 2001, 20(4-7), 1025-1028.
[3] Ying C, et al. J Viral Hepat, 2000, 7(2), 161-165.
[4] Wainberg MA, et al. Antivir Ther, 1999, 4(2), 87-94.
[5] De Clercq E, et al. Clin Microbiol Rev, 2003, 16(4), 569-596.
[2] Miller MD, et al. Nucleosides Nucleotides Nucleic Acids, 2001, 20(4-7), 1025-1028.
[3] Ying C, et al. J Viral Hepat, 2000, 7(2), 161-165.
[4] Wainberg MA, et al. Antivir Ther, 1999, 4(2), 87-94.
[5] De Clercq E, et al. Clin Microbiol Rev, 2003, 16(4), 569-596.
Synonyms
Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
(R)-9-(2-Phosphonomethoxypropyl)adenine
Tenofovir
PMPA
GS 1275
GS 1278
Tenefovir
[(2R)-1-(6-Aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid
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