[CAS NO. 81403-68-1] Alfuzosin HCl

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PRODUCTS SPECIFICATIONS [81403-68-1]

Catalog

SLK-S1409

Brand

Selleck

CAS

81403-68-1

DESCRIPTION [81403-68-1]

Overview

MDL	MFCD00879135
Molecular Weight	425.91
Molecular Formula	C19H27N5O4.HCl
SMILES	NC=1C2=C(N=C(N(CCCNC(=O)C3CCCO3)C)N1)C=C(OC)C(OC)=C2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3479 mL	11.7396 mL	23.4791 mL
5 mM	0.4696 mL	2.3479 mL	4.6958 mL
10 mM	0.2348 mL	1.1740 mL	2.3479 mL
50 mM	0.0470 mL	0.2348 mL	0.4696 mL

Description

Alfuzosin HCI(SL 77499 HCl) is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

Targets

α1-adrenergic receptor ^[1]

In vitro

Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold. Alfuzosin shows a concentration-dependent relaxing effect on rabbit corpus cavernosum (CC) pre-contracted by 10 mM phenylephrine.

References

[1] Lacerda AE, et al. J Pharmacol Exp Ther,?008, 324(2), 427-433.
[2] Palea S, et al. BJU Int,?003, 91(9), 873-877.
[3] Mayoux E, et al. Eur Urol,?004, 45(1), 110-116.
[4] Tambaro S, et al. J Pharmacol Exp Ther,?005, 312(2), 710-717.
[5] Lef鑦re-Borg F, et al. Br J Pharmacol,?993, 109(4), 1282-1289.

Synonyms

2-Furancarboxamide, N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-, hydrochloride (1:1)

2-Furancarboxamide, N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-, monohydrochloride

Alfuzosin hydrochloride

Xatral

Urion

SL 77499-10

Alfoten

SL 77-499-10

Uroxatral