[CAS NO. 15686-71-2] Cephalexin

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PRODUCTS SPECIFICATIONS [15686-71-2]

Catalog

SLK-S1502

Brand

Selleck

CAS

15686-71-2

DESCRIPTION [15686-71-2]

Overview

MDL	MFCD00056877
Molecular Weight	347.39
Molecular Formula	C16H17N3O4S
SMILES	O=C1N2[C@@]([C@@H]1NC([C@H](N)C3=CC=CC=C3)=O)(SCC(C)=C2C(O)=O)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8786 mL	14.3930 mL	28.7861 mL
5 mM	0.5757 mL	2.8786 mL	5.7572 mL
10 mM	0.2879 mL	1.4393 mL	2.8786 mL
50 mM	-	-	-

Description

Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.

In vitro

Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibits saturable kinetics with K(m) = 5.9 mM and a bell-shaped pH profile with a maximum at pH 7.0. Cephalexin results in overestimation of glucose concentration, but only in the samples that contain the highest antimicrobial concentration (2,400microg/mL) and only for the tablet. Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells.

In vivo

Cephalexin causes a slight prolongation of 1-stage prothrombin time (PT) and activated partial thromboplastin time (PTT) and slight decrease in fibrinogen concentration in healthy dogs. Cephalexin causes a significant increase in 1-stage PT and activated PTT, amoxicillin causes a significant increase in activated PTT, and enrofloxacin causes a significant decrease in fibrinogen concentration. Cephalexin results in high numbers of E. coli producing plasmid-mediated CMY-2 β-lactamase at the end of the treatment period in dogs.

References

[1] Watanabe S, et al. J Pharmacol Exp Ther, 2010, 334(2), 651-656.
[2] Rees CA, et al. J Am Vet Med Assoc, 2004, 224(9), 1455-1458.
[3] Zarebska A, et al. Ann Univ Mariae Curie Sklodowska Med, 2004, 59(1), 145-150.
[4] Webb JA, et al. Am J Vet Res, 2006, 67(4), 569-576.
[5] Damborg P, et al. Vet Microbiol, 2011, 151(3-4), 404-408.

Synonyms

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-, (6R,7R)-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-, D-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-, [6R-[6α,7β(R*)]]-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-aminophenylacetyl]amino]-3-methyl-8-oxo-, (6R,7R)-

(6R,7R)-7-[[(2R)-2-Amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cephalexin

7-(α-Amino-D-phenylacetamido)-3-deacetoxycephalosporanic acid

7-[D-(-)-α-Aminophenylacetamido]-3-methyl-3-cephem-4-carboxylic acid

Ceporexine

Cefalexin

Keflex

Keforal

Lilly 66873

Larixin

S 6437

Oroxin

Ceporexin

Oracef

Ceforal

Palitrex

L-Keflex

Syncl

Cephacillin

Cephamasten

Lafarine

D-Cephalexin

Cepexin

Cephalexine

Ceporex

Cefaleksin

Tepaxin

Kefloridina

Sialexin

Novolexin

Medoxine

Kekrinal

Ibilex

Nufex

Ceporex Forte

Oriphex

Alsporin

Mamlexin

Cophalexin

Sporidex

Inphalex

Ibrexin

Cefadina

Servispor

Kefalospes

Uphalexin

Cefadal

Kefalex

Kidolex

Madlexin

Sinthecillin

Celexin

Cefadin

Kefexin

Voxxim

Lopilexin

Syncle

Check

Winlex

Pyassan

Neokef

Lonflex

Cephaxin

Erocetin

Sanaxin

Cefalin

Sporicef

Keflet

Mamalexin

Cefablan

Ospexin

Carnosporin

Felexin

Sepexin

Septilisin

Rofex

Tokiolexin

Durantel DS

Cephin

Durantel

Ed A-Ceph

Biocef

Cefovit

Naxifelar

Cefaseptin

Fexin

Cepastar

Alcephin

Cepol

Synecl

Kefaxin

Lenocef

Cefadyl

Pectril

Cerexin

Iwalexin

Llonexina

Cefadros

Cex

Cefaloto

Farexin

Xahl

Derantel

Sencephalin

Oracocin

Rinesal

Mecilex

Ohlexin

Fergon 500

Taicelexin

Lexibiotico

Cefanex

Sintolexyn

Efalexin

Garasin

Phexin

Larixin (antibiotic)

Vetolexin

Lixen-IU