[CAS NO. 22254-24-6] Ipratropium Bromide

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PRODUCTS SPECIFICATIONS [22254-24-6]

Catalog

SLK-S1683

Brand

Selleck

CAS

22254-24-6

DESCRIPTION [22254-24-6]

Overview

MDL	MFCD00069291
Molecular Weight	412.37
Molecular Formula	C20H30BrNO3
SMILES	C(C)(C)[N@+]1(C)[C@H]2C[C@H](OC(C(CO)C3=CC=CC=C3)=O)C[C@@H]1CC2.[Br-]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4250 mL	12.1250 mL	24.2501 mL
5 mM	0.4850 mL	2.4250 mL	4.8500 mL
10 mM	0.2425 mL	1.2125 mL	2.4250 mL
50 mM	0.0485 mL	0.2425 mL	0.4850 mL

Description

Ipratropium Bromide is an antagonist of M3 type , used for the treatment of chronic obstructive pulmonary disease (COPD).

Targets

mAChR ^[1]

In vitro

Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis. Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca(2+)-entry.

In vivo

Ipratropium dry powder inhalation (DPI) at a dose of 2400 mg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. Ipratropium significantly attenuates the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium treated rats. Ipratropium bromide partially protects the lungs against the inflammation by reducing neutrophilic infiltration. Ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirms its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle in the guinea-pig. Ipratropium decreases the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increases dynamic compliance (Cdyn) in horse.

References

[1] Zhang W, et al. Eur J Pharmacol,?010, 647(1-3), 178-187.
[2] Shaik N, et al. Cell Physiol Biochem,?012, 30(6), 1517-1525.
[3] Duvivier DH, et al. Equine Vet J,?999, 31(1), 20-24.
[4] Zhang W, et al. Eur J Pharmacol,?010, 628(1-3), 171-178.
[5] Fryer AD, et al. Eur J Pharmacol,?987, 139(2), 187-191.
[6] Robinson NE, et al. Equine Vet J,?993, 25(4), 299-303.

Synonyms

8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide (1:1), (3-endo,8-syn)-

1αH,5αH-Tropanium, 3α-hydroxy-8-isopropyl-, bromide, (±)-tropate

8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)-(±)-

8-Isopropylatropinium bromide

8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (3-endo,8-syn)-

Sch 1000

Atrovent

Ipratropium bromide

N-Isopropylatropinium bromide

8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)-

Sch 100

N-Isopropylnoratropinium bromomethylate

Atrovent forte

Aerovent

Ipraxa