[CAS NO. 83919-23-7] Mometasone furoate
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PRODUCTS SPECIFICATIONS [83919-23-7]
Distributor
Catalog
SLK-S1987
Brand
Selleck
CAS
83919-23-7
DESCRIPTION [83919-23-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 521.43 |
| Molecular Formula | C27H30Cl2O6 |
| SMILES | O(C(=O)C1=CC=CO1)[C@@]2(C(CCl)=O)[C@]3(C)[C@@](C[C@H]2C)([C@]4([C@](Cl)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9178 mL | 9.5890 mL | 19.1780 mL |
| 5 mM | 0.3836 mL | 1.9178 mL | 3.8356 mL |
| 10 mM | 0.1918 mL | 0.9589 mL | 1.9178 mL |
| 50 mM | - | - | - |
Description
Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a agonist, used topically to reduce inflammation of the skin or in the airways.
Targets
| Glucocorticoid receptor [1] |
In vitro
Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response.
References
[1] Magari M, et al. Immunopharmacol Immunotoxicol,?006, 28(3), 491-500.
[2] Tsumuro T, et al. Eur J Pharmacol,?005, 524(1-3), 155-158.
[3] Wyss D, et al. Br J Pharmacol,?007, 152(1), 83-90.
[4] Sugimoto Y, et al. Pharmacology,?000, 61(2), 91-95.
[5] Chapman RW, et al. Arzneimittelforschung,?998, 48(4), 384-391.
[2] Tsumuro T, et al. Eur J Pharmacol,?005, 524(1-3), 155-158.
[3] Wyss D, et al. Br J Pharmacol,?007, 152(1), 83-90.
[4] Sugimoto Y, et al. Pharmacology,?000, 61(2), 91-95.
[5] Chapman RW, et al. Arzneimittelforschung,?998, 48(4), 384-391.
Synonyms
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-, (11β,16α)-
(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
Mometasone furoate
Sch 32088
Nasonex
Mometasone 17-(2-furoate)
Elocon
Elomet
Elocom
Ecural
Asmanex
Asmanex Twisthaler
Twisthaler
Monovo
Ovixan
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