[CAS NO. 83915-83-7] Lisinopril dihydrate

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PRODUCTS SPECIFICATIONS [83915-83-7]

Catalog

SLK-S2076

Brand

Selleck

CAS

83915-83-7

DESCRIPTION [83915-83-7]

Overview

MDL	MFCD01698825
Molecular Weight	441.52
Molecular Formula	C21H35N3O7
SMILES	C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCCN)(=O)N2[C@H](C(O)=O)CCC2.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2649 mL	11.3245 mL	22.6490 mL
5 mM	0.4530 mL	2.2649 mL	4.5298 mL
10 mM	0.2265 mL	1.1325 mL	2.2649 mL
50 mM	0.0453 mL	0.2265 mL	0.4530 mL

Description

Lisinopril dihydrate(MK-521 dihydrate) is an inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

Targets

ACE ^[1]

In vitro

Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril.

References

[1] Nemoto S, et al. J Am Coll Cardiol,?002, 40(1), 149-154.
[2] Swaan PW, et al. Biochim Biophys Acta,?995, 1236(1), 31-38.
[3] Mantle D, et al. Clin Chim Acta, 2000, 299(1-2), 1-10.
[4] Mohammadi-Karakani A, et al. Clin Chim Acta,?006, 367(1-2), 170-174.
[5] Duman S, et al. Int J Artif Organs,?005, 28(2), 156-163.
[6] Selim Isbir C, et al. Cell Biochem Funct,?000, 18(2), 85-91.

Synonyms

L-Proline, N²-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2)

L-Proline, 1-[N²-(1-carboxy-3-phenylpropyl)-L-lysyl]-, dihydrate, (S)-

L-Proline, N²-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, dihydrate

Lisinopril dihydrate