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Catalog:
SLK-S2201
Brand:
Selleck
CAS:
1174046-72-0
Overview
MDL
MFCD18206786
Molecular Weight
468.84
Molecular Formula
C23H15ClF2N4O3
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.1329 mL
10.6646 mL
21.3292 mL
5 mM
0.4266 mL
2.1329 mL
4.2658 mL
10 mM
0.2133 mL
1.0665 mL
2.1329 mL
50 mM
0.0427 mL
0.2133 mL
0.4266 mL
Description
BMS-794833 is a potent ATP competitive inhibitor of with of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.
BMS794833 also inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with IC50 of 39 nM.
In vivo
In GTL-16 human gastric tumor xenografts model, BMS798433 shows greater than 50% TGI for at least one tumor doubling time with no overt toxicity observed during 14 days. BMS798433 also shows complete tumor stasis at a dose of 25 mg/kg against U87 glioblastoma model.
