[CAS NO. 1180-71-8] Limonin

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Catalog:	SLK-S2319
Brand:	Selleck
CAS:	1180-71-8

Overview

MDL	MFCD00075922
Molecular Weight	470.51
Molecular Formula	C26H30O8
SMILES	C[C@]12[C@]34[C@](O3)(C(=O)O[C@]([C@]4(C)CC[C@@]1([C@]56[C@@](CC2=O)(C(C)(C)O[C@]5(CC(=O)OC6)[H])[H])[H])(C=7C=COC7)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1254 mL	10.6268 mL	21.2535 mL
5 mM	0.4251 mL	2.1254 mL	4.2507 mL
10 mM	0.2125 mL	1.0627 mL	2.1254 mL
50 mM	0.0425 mL	0.2125 mL	0.4251 mL

Description

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

Targets

HIV protease ^[1]

In vitro

Limonin is a furanolactone enriched in citrus fruits, which has antivirus and antitumor ability. Limonin inhibits the replication of human immunodeficiency virus-1 (HIV-1) in culture of human peripheral blood mononuclear cells (PBMC) with an EC50 of 60 μM. Limonin also shows antinociceptive and anti-inflammatory effects in vivo. Limonin is a potent anti proliferative agent against human hepatoma HepG2 cells via regulation of apoptosis and Wnt signallings.

References

[1] Battinelli L, et al. Planta Med, 2003, 69(10), 910-913.
[2] Matsuda H, et al. Planta Med, 1998, 64(4), 339-342.
[3] Langeswaran K, et al. J Nat Sci Biol Med, 2013, 4(1), 126-133.

Synonyms

11H,13H-Oxireno[d]pyrano[4′,3′:3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione, 8-(3-furanyl)decahydro-2,2,4a,8a-tetramethyl-, (2aR,4aR,4bR,5aS,8S,8aS,10aR,10bR,14aS)-

11H,13H-Oxireno[d]pyrano[4′,3′:3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione, 8-(3-furyl)decahydro-2,2,4a,8a-tetramethyl-

Limonin

Limonoic acid, di-δ-lactone

(2aR,4aR,4bR,5aS,8S,8aS,10aR,10bR,14aS)-8-(3-Furanyl)decahydro-2,2,4a,8a-tetramethyl-11H,13H-oxireno[d]pyrano[4′,3′:3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione

Citrolimonin

Dictamnolactone

Evodin

11H,13H-Oxireno[d]pyrano[4′,3′:3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione, 8-(3-furanyl)decahydro-2,2,4a,8a-tetramethyl-, [2aR-(2aα,4aβ,4bR*,5aα,8α,8aα,10aα,10bR*,14aα)]-

Obaculactone

Limonine

7,16-Dioxo-7,16-dideoxylimondiol

Obakulactone

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