[CAS NO. 19057-60-4] Dioscin

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PRODUCTS SPECIFICATIONS [19057-60-4]

Catelog

SLK-S2379

Brand

Selleck

CAS

19057-60-4

DESCRIPTION [19057-60-4]

Overview

MDL	MFCD02094174
Molecular Weight	869.04
Molecular Formula	C45H72O16
SMILES	C[C@@]12[C@@]3([C@](C[C@]1([C@]4([C@](CC2)([C@]5(C)C(=CC4)C[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](CO)O6)CC5)[H])[H])[H])(O[C@@]9([C@H]3C)CC[C@@H](C)CO9)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.1507 mL	5.7535 mL	11.5070 mL
5 mM	0.2301 mL	1.1507 mL	2.3014 mL
10 mM	0.1151 mL	0.5753 mL	1.1507 mL
50 mM	0.0230 mL	0.1151 mL	0.2301 mL

Description

Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.

In vitro

Dioscin is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. Dioscin induces apotosis in Hela cells by down regulating caspase-8 activity and up regulating caspase-9 activity.

In vivo

LD50: Mice >300mg/kg

References

[1] Wang Z, et al. Biol Pharm Bull, 2001, 24(2), 159-162.
[2] Cai J, et al. Biol Pharm Bull. 2002, 25(2), 193-196.

Synonyms

β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-

Dioscin

(3β,25R)-Spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside

Dioscine

Diosgenin bis-α-L-rhamnopyranosyl-(1→2 and 1→4)-β-D-glucopyranoside

Collettiside III

(+)-Dioscin

Polyphyllin III

Diosgenin 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside

3-O-β-D-α-L-Rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranoside-diosgenin

Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside

Paris III

Parissaponin III