[CAS NO. 860-79-7] Cyclovirobuxine D

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PRODUCTS SPECIFICATIONS [860-79-7]

Catelog

SLK-S2402

Brand

Selleck

CAS

860-79-7

DESCRIPTION [860-79-7]

Overview

MDL	-
Molecular Weight	402.66
Molecular Formula	C26H46N2O
SMILES	C[C@]12[C@]3([C@]4([C@]5(C4)[C@](C(C)(C)[C@@H](NC)CC5)(CC3)[H])CC[C@]1(C)[C@@]([C@@H](NC)C)([C@H](O)C2)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Cyclovirobuxine D (Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.

In vitro

Cyclovirobuxine D increases cardiomyocytes viability injured by oxidation or hypoxia. It significantly reduces the infarct size induced by ligating the coronary artery in rats. In addition, Cyclovirobuxine D protects rat aorta endothelial cells against hypoxia and enhanced nitric oxide (NO) release from endothelial cells. Cyclovirobuxine D facilitates the utilization of intracellular Ca(2+) and prevents the loss of Ca(2+), which may be the underlying mechanism of its protective effect on heart failure.

In vivo

Cyclovirobuxine D decreases the weight of venous thrombus in rats. Cyclovirobuxine D causes a primary effect of coronary vasodilatation in anesthetized pigs, which involves mechanisms related to the endothelial release of nitric oxide. In addition, Cyclovirobuxine D is beneficial for heart failure in rats induced by myocardial infarction. LD50: Mice 8.9mg/kg (i.v.), 9.2mg/kg (i.p.), 293mg/kg (i.g.).

References

[1] Hu D, et al. Eur J Pharmacol, 2007, 569(1-2), 103-109.
[2] Grossini E, et al. Life Sci, 1999, 65(5), PL59-65.
[3] Yu B, et al. Fitoterapia. 2011, 82(6), 868-877.
[4] Yu B, et al. Fitoterapia. 2012, 83(8):1653-1665.

Synonyms

9,19-Cyclopregnan-16-ol, 4,4,14-trimethyl-3,20-bis(methylamino)-, (3β,5α,16α,20S)-

9,19-Cyclo-5α,9β-pregnan-16α-ol, 4,4,14-trimethyl-3β,20α-bis(methylamino)-

1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene, 9,19-cyclopregnan-16-ol deriv.

(3β,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol

Cyclovirobuxine

Cyclovirobuxine D

Bebuxine

Cyclovirobuxin D

NSC 91722

Cyclovirobuxinum D

(3α,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol

CVB-D