[CAS NO. 1020315-31-4] PF-04457845
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PRODUCTS SPECIFICATIONS [1020315-31-4]
Catalog
SLK-S2421
Brand
Selleck
CAS
1020315-31-4
DESCRIPTION [1020315-31-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 455.43 |
| Molecular Formula | C23H20F3N5O2 |
| SMILES | C(NC1=CC=CN=N1)(=O)N2CCC(=CC3=CC(OC4=CC=C(C(F)(F)F)C=N4)=CC=C3)CC2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1957 mL | 10.9786 mL | 21.9573 mL |
| 5 mM | 0.4391 mL | 2.1957 mL | 4.3915 mL |
| 10 mM | 0.2196 mL | 1.0979 mL | 2.1957 mL |
| 50 mM | 0.0439 mL | 0.2196 mL | 0.4391 mL |
Description
PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.
Synonyms
1-Piperidinecarboxamide, N-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-
N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
PF 04457845
PF 4457845
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